Sodium Hydroxide → 1-(3-chloropyridin-2-yl)-4-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]acetyl}-1H-pyrrole-2-carboxylic acid

HRID 874193노트

반응식

HRID 874193 반응식
[Cl:1][C:2]1[C:3]([N:8]2[CH:12]=[C:11]([C:13](=[O:24])[CH2:14][N:15]3[N:19]=[N:18][C:17]([C:20]([F:23])([F:22])[F:21])=[N:16]3)[CH:10]=[C:9]2[C:25]([O:27]C)=[O:26])=[N:4][CH:5]=[CH:6][CH:7]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:3]([N:8]2[CH:12]=[C:11]([C:13](=[O:24])[CH2:14][N:15]3[N:19]=[N:18][C:17]([C:20]([F:21])([F:22])[F:23])=[N:16]3)[CH:10]=[C:9]2[C:25]([OH:27])=[O:26])=[N:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67125230methyl 1-(3-chloropyridin-2-yl)-4-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]acetyl}-1H-pyrrole-2-carboxylate

생성물 1

HCID 671252351-(3-chloropyridin-2-yl)-4-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]acetyl}-1H-pyrrole-2-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

130 mg (0.31 mmol) of methyl 1-(3-chloropyridin-2-yl)-4-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]acetyl}-1H-pyrrole-2-carboxylate were dissolved in 3 ml of ethanol, 19 mg (0.47 mmol) of 2N aqueous sodium hydroxide solution were added and the mixture was stirred at RT for 4 h. The solvent was distilled off under reduced pressure, the residue was taken up in water and the mixture was extracted once with methyl tert-butyl ether. The aqueous phase was then acidified with 2N hydrochloric acid and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulphate and concentrated.

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. extractionthe mixture was extracted once with methyl tert-butyl ether
  3. extractionextracted three times with ethyl acetate
  4. dry with materialThe combined organic phases were dried over sodium sulphate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5c3d320cabb2457e890127bc1f6e0e3e
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980886B2

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