Trimethylsilyldiazomethane → 1-N-Boc-4-Piperidinecarboxylic acid methyl ester
반응식
[C:1]([N:8]1[CH2:16][CH2:15][CH:11]([C:12]([OH:14])=[O:13])[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:17][Si](C=[N+]=[N-])(C)C>ClCCl.CO>[C:4]([O:3][C:1]([N:8]1[CH2:16][CH2:15][CH:11]([C:12]([O:14][CH3:17])=[O:13])[CH2:10][CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]참가 물질
4
실험 절차
To a solution of BOC-isonipecotic acid (45.0 g, 0.20 mol) dissolved in a 3:1 solution of dichloromethane/methanol (1200 mL) at 0° C. was added a solution of trimethylsilyldiazomethane (147 mL, 0.29 mol, 2.0M in hexane) over 30 min via an addition funnel. The reaction mixture was then concentrated to afford the title compound (47 g) as a light yellow oil. This was used directly in the next step without further purification.
후처리
- concentrationThe reaction mixture was then concentrated
출처 및 근거
- ORD 기록
- ord-b2d23674e1954e95b0862e72fba9eb4a
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07091211B2
반응 노트
불러오는 중…