Benzene → Methyl 2-nitrobenzoate

HRID 874862

반응식

HRID 874862 반응식
[N+:1]([C:4]1[C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)(Cl)=O.[CH:17]1C=CC=CC=1>>[CH3:17][O:11][C:10](=[O:12])[C:9]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 3

HCID 241BenzeneHCID 110872-Nitrobenzoic acidHCID 24386Thionyl Chloride

생성물 1

HCID 69072Methyl 2-nitrobenzoate

실험 절차

A solution of 6-nitro-benzoic acid in benzene was treated with thionyl chloride (2.5 eq) and stirred at reflux for 8 h. After evaporation, the residue was dissolved in chloroform and then treated with methanol. After stirring at reflux for 3 h, the mixture was evaporated to afford compound 3.

후처리

  1. temperatureat reflux for 8 h
  2. customAfter evaporation
  3. dissolutionthe residue was dissolved in chloroform
  4. additiontreated with methanol
  5. stirringAfter stirring
  6. temperatureat reflux for 3 h
  7. customthe mixture was evaporated

출처 및 근거

ORD 기록
ord-3ab26dc5f94c470a80020d25845e6083
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980901B2

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