Hydrochloric Acid → 1-Acetyl-4-hydrazinopiperidine hydrochloride

HRID 875150노트

반응식

HRID 875150 반응식
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([N:10](C(OC(C)(C)C)=O)[NH:11]C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:26]>CO.O1CCOCC1>[ClH:26].[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([NH:10][NH2:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 57444162Di-tert-butyl 1-(1-acetylpiperidin-4-yl)hydrazine-1,2-dicarboxylate

생성물 1

HCID 574441611-Acetyl-4-hydrazinopiperidine hydrochloride수율 77%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

32 g (0.09 mol) of di-tert-butyl 1-(1-acetylpiperidin-4-yl)hydrazine-1,2-dicarboxylate were dissolved in 300 mL of methanol and 30 mL of HCl 4 M in dioxane were added. The mixture was stirred at room temperature overnight. The solvent was then evaporated and the residue crystallized from ethanol, giving 14 g (77% yield) of the title compound.

후처리

  1. customThe solvent was then evaporated
  2. customthe residue crystallized from ethanol

출처 및 근거

ORD 기록
ord-3e717bb06c3c47c68196028ea6748b3d
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08981089B2

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