Hydrochloric Acid → (1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

HRID 875153

반응식

HRID 875153 반응식
C(OC([NH:8][C@@:9]([CH3:24])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=[O:11])=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[CH3:24][C@:9]([NH2:8])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1)=[O:11]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57444165tert-butoxycarbonyl-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine

생성물 1

HCID 57444166(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of 630 mg (1.884 mmol) of N-(tert-butoxycarbonyl)-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine in 20 mL of dioxane was treated with 2.5 mL of HCl 4N in dioxane overnight. The solvent was removed under vacuo and the solid was triturated with diethylether yielding 560 mg of the title compound.

후처리

  1. customThe solvent was removed under vacuo
  2. customthe solid was triturated with diethylether yielding 560 mg of the title compound

출처 및 근거

ORD 기록
ord-40e08d9d40fc444d99428ac378a1c5c8
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08981089B2

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