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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrazine hydrate (1:1) → 6-{[({(3-Bromo-4-methoxyphenyl)[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylene}amino)oxy]methyl}pyridin-2-amine

HRID 875200
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HRID 875200 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:10](=[N:22][O:23][CH2:24][C:25]2[N:30]=[C:29]([N:31]3C(=O)C4C(=CC=CC=4)C3=O)[CH:28]=[CH:27][CH:26]=2)[C:11]2[C:16]([Cl:17])=[CH:15][C:14]([C:18]([F:21])([F:20])[F:19])=[CH:13][N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O.NN>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]([C:10](=[N:22][O:23][CH2:24][C:25]2[N:30]=[C:29]([NH2:31])[CH:28]=[CH:27][CH:26]=2)[C:11]2[C:16]([Cl:17])=[CH:15][C:14]([C:18]([F:20])([F:21])[F:19])=[CH:13][N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 866507382-(6-{[({(3-bromo-4-methoxyphenyl)[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylene}amino)oxy]methyl}pyridin-2-yl)-1H-isoindole-1,3(2H)-dione

생성물 1

HCID 866507396-{[({(3-Bromo-4-methoxyphenyl)[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylene}amino)oxy]methyl}pyridin-2-amine수율 75%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-(6-{[({(3-bromo-4-methoxyphenyl)[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylene}amino)oxy]methyl}pyridin-2-yl)-1H-isoindole-1,3(2H)-dione (7.00 g, 9.75 mmol) in tetrahydrofuran (150 mL) was added hydrazine hydrate (2.37 mL, 48.7 mmol) dropwise. After stirring overnight at room temperature, the reaction mixture was filtered, and the filtrate concentrated in vacuo. Purification on silica gel afforded 6-{[({(3-bromo-4-methoxyphenyl)[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylene}amino)oxy]methyl}pyridin-2-amine as an oil [4.00 g, yield 75%; HPLC/MS: m/z=516 (M+H); log P(HCOOH)=2.54].

후처리

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate concentrated in vacuo
  3. customPurification on silica gel

출처 및 근거

ORD 기록
ord-cdc46676546946a5afb8e8bf7144e3cc
출처 데이터셋
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08981111B2

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