Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide

HRID 875381

반응식

HRID 875381 반응식
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 2431652-Amino-4-methyl-5-nitropyridine

생성물 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamide수율 87%

반응 조건

온도
90 °C

실험 절차

A mixture of 4-methyl-5-nitropyridin-2-amine (5 g, 32 mmol) and acetic anhydride (20 mL) was heated at 90° C. for 4 hours. After cooling the solvent was evaporated under vacuum. The concentrated mass was dissolved in toluene and evaporated under vacuum. The resulting solid was triturated with diethyl ether and filtered to afford N-(4-methyl-5-nitropyridin-2-yl) acetamide (5.5 g, 87%).

후처리

  1. temperatureAfter cooling the solvent
  2. customwas evaporated under vacuum
  3. dissolutionThe concentrated mass was dissolved in toluene
  4. customevaporated under vacuum
  5. customThe resulting solid was triturated with diethyl ether
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-d06bd54f5f924e2ebe9150a2b1d7623e
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980911B2

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