Sodium Hydroxide → 1-Methyl 2,6-dichloro-1,4-benzenedicarboxylate

HRID 875386

반응식

HRID 875386 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([O:10]C)=[O:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[C:13]([O:15][CH3:16])=[O:14].[OH-].[Na+]>O1CCCC1.O>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([Cl:12])[C:3]=1[C:13]([O:15][CH3:16])=[O:14])[C:8]([OH:10])=[O:9]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 7730227Dimethyl 2,6-dichloroterephthalate

생성물 1

HCID 186730161-Methyl 2,6-dichloro-1,4-benzenedicarboxylate수율 85%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To the stirred solution of dimethyl 2,6-dichlorobenzene-1,4-dicarboxylate (2 g, 7.6 mmol, Step b) in tetrahydrofuran and water (1:1, 20 mL), sodium hydroxide (304 mg, 7.6 mmol) was added and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under vacuum and the residue was neutralized using cold hydrochloric acid (1N). The precipitated solid was filtered under suction, washed with hexane and dried to afford 3,5-dichloro-4-(methoxycarbonyl)benzoic acid as an white solid (1.5 g, 85%).

후처리

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. filtrationThe precipitated solid was filtered under suction
  3. washwashed with hexane
  4. customdried

출처 및 근거

ORD 기록
ord-ab3a71d21de342cca5cba42610df5003
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08980911B2

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