Sodium Hydroxide → 7-Chloro-2-methyl-1H-pyrrolo[2,3-C]pyridine
반응식
[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[CH:10]=[C:9]([CH3:11])[N:8](S(C3C=CC=CC=3)(=O)=O)[C:7]=12.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[CH:10]=[C:9]([CH3:11])[NH:8][C:7]=12참가 물질
4
실험 절차
To a solution of 7-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-c]pyridine (220 mg, 0.71 mmol) in ethanol (10 mL), a solution of sodium hydroxide (10%, 6 mL) was added and the reaction mixture was stirred at room temperature for about 16 hours. The solvent was removed under vacuum. The residue was taken up in ethyl acetate washed with water and brine, dried over anhydrous sodium sulfate & concentrated under vacuum to give 7-chloro-2-methyl-1H-pyrrolo[2,3-c]pyridine (110 mg, 92% yield).
후처리
- customThe solvent was removed under vacuum
- washwashed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- concentrationconcentrated under vacuum
출처 및 근거
- ORD 기록
- ord-fb55c381f7f246e2b02d4e4932adcc3c
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08980911B2
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