N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

HRID 876247

반응식

HRID 876247 반응식
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[N:13][CH:14]=2)=[CH:5][CH:4]=1>C(O)(=O)C>[F:24][C:2]([F:1])([F:25])[C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([NH:15][C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:23])[CH2:10]2)=[CH:7][CH:8]=1

참가 물질

3

반응물 1

HCID 66701368N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide

생성물 1

HCID 66701397N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 1.0 g (2.9 mmol) of N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 120 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 657 mg (50% pure).

후처리

  1. concentrationThe solution was concentrated under reduced pressure
  2. customThe product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)

출처 및 근거

ORD 기록
ord-2e9c2f26daaf444dabbf4bcb30935231
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987248B2

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