Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide → N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide | HCID 66701368 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | N-{5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}benzamide | HCID 66701397 | — |
반응 단계
A solution of 1.0 g (2.9 mmol) of N-{5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]benzamide in 120 ml of glacial acetic acid was reacted according to General Method 6A. The solution was concentrated under reduced pressure. The product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 657 mg (50% pure).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08987248B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-2e9c2f26daaf444dabbf4bcb30935231 |
| 출처 메모 | uspto-grants-2015_03 |