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Hydrochloric Acid → 2-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)-8-((cis)-3-fluoropiperidin-4-yloxy)quinoline dihydrochloride

HRID 876485
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HRID 876485 반응식
[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:20][C@H:21]4[CH2:26][CH2:25][NH:24][CH2:23][C@H:22]4[F:27])[CH:14]=[CH:15][CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:28].O1CCOCC1>CO>[ClH:28].[ClH:28].[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:20][C@H:21]4[CH2:26][CH2:25][NH:24][CH2:23][C@H:22]4[F:27])[CH:14]=[CH:15][CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 672309412-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)-8-((cis)-3-fluoropiperidin-4-yloxy)quinoline

생성물 1

HCID 672349172-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)-8-((cis)-3-fluoropiperidin-4-yloxy)quinoline dihydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Non-racemic 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-((cis)-3-fluoropiperidin-4-yloxy)quinoline (20 mg, 0.055 mmol) was dissolved in MeOH (2 mL) and treated with 4M HCl in dioxane (1 mL, 4 mmol). The mixture was stirred for 5 minutes then concentrated in vacuo. The residue was dissolved in fresh MeOH and concentrated in vacuo three times to a pale yellow solid (20.7 mg, 86%). Specific rotation: [α]20D=+26° (c=0.45, 1:1 water/95% ethanol).

후처리

  1. concentrationthen concentrated in vacuo
  2. dissolutionThe residue was dissolved in fresh MeOH
  3. concentrationconcentrated in vacuo three times to a pale yellow solid (20.7 mg, 86%)

출처 및 근거

ORD 기록
ord-30951e6add064d31a791c81134cd7c10
출처 데이터셋
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08987251B2

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