Hydrochloric Acid → (R)-4-(2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-yloxy)-3,3-dimethylbutane-1,2-diol dihydro chloride

HRID 876499노트

반응식

HRID 876499 반응식
[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:21][CH2:22][C:23]([C@@H:26]4[CH2:30][O:29]C(C)(C)[O:27]4)([CH3:25])[CH3:24])[CH:14]=[C:15]([F:20])[CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[ClH:33]>CO>[ClH:33].[ClH:33].[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:21][CH2:22][C:23]([CH3:25])([CH3:24])[C@@H:26]([OH:27])[CH2:30][OH:29])[CH:14]=[C:15]([F:20])[CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67234098(R)-2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropoxy)-6-fluoroquinoline

생성물 1

HCID 67233773(R)-4-(2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-6-fluoroquinolin-8-yloxy)-3,3-dimethylbutane-1,2-diol dihydro chloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

(R)-2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropoxy)-6-fluoroquinoline (0.190 g, 0.435 mmol) was added to methanol saturated with HCl and stirred for 30 minutes. The solution was evaporated, DCM was added, and the material triturated and filtered to yield 140 mgs of the desired product as orange solid. MS ESI (+) m/z 397 (M+1) detected.

후처리

  1. customThe solution was evaporated
  2. additionDCM was added
  3. customthe material triturated
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-787a7517b821416795892d68957459e5
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987251B2

반응 노트

불러오는 중…