Water → HCID 15123266, 화합물

HRID 876551

반응식

HRID 876551 반응식
C([O-])([O-])=O.[K+].[K+].Cl[CH2:8][C:9]1[N:14]=[C:13]([C:15]([O:17][CH3:18])=[O:16])[CH:12]=[CH:11][CH:10]=1.[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1.O>CN(C=O)C>[N:19]1([CH2:8][C:9]2[N:14]=[C:13]([C:15]([O:17][CH3:18])=[O:16])[CH:12]=[CH:11][CH:10]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 53404482Methyl 6-(chloromethyl)pyridine-2-carboxylate

생성물 1

HCID 15123266HCID 15123266, 화합물수율 67.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

K2CO3 (66 g, 0.48 mol) was added to a solution of methyl 6-(chloromethyl)picolinate 71 (45.0 g) and pyrrolidine 72 (34 g, 0.48 mol) in DMF (300 mL). The reaction mixture was heated at 80° C. for 12 h. H2O (300 mL) was added and the mixture was extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4) and concentrated in vacuo to give 73 (36 g).

후처리

  1. extractionthe mixture was extracted with EtOAc
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-4bd2e1c68df848a588d9c270987f3432
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987258B2

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