Hydrochloric Acid → 4-bromo-1H-indazole

HRID 876563

반응식

HRID 876563 반응식
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][N:6]2C(=O)C.Cl>CO>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 454801851-Acetyl-4-bromo-1H-indazole

생성물 1

HCID 223525484-bromo-1H-indazole수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of the 1-(4-bromo-indazol-1-yl)-ethanone (3.09 g, 12.9 mmol) in MeOH (50 mL) was added 6N aqueous HCl (30 mL) and the mixture was stirred at room temperature for 7 h. The MeOH was evaporated and the mixture partitioned between EtOAc (2×50 mL) and water (50 mL). The combined organic layers were washed with brine (50 mL), separated and dried (MgSO4). The solvent was removed by evaporation under reduced pressure to give 4-bromo-1H-indazole (2.36 g, 93%).

후처리

  1. customThe MeOH was evaporated
  2. customthe mixture partitioned between EtOAc (2×50 mL) and water (50 mL)
  3. washThe combined organic layers were washed with brine (50 mL)
  4. customseparated
  5. dry with materialdried (MgSO4)
  6. customThe solvent was removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-ba6f684c3a0c42d89368aa7473db13d0
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987260B2

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