Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 876659노트

반응식

HRID 876659 반응식
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.Cl.[OH:10][CH:11]1[CH2:14][NH:13][CH2:12]1.[OH-].[Na+]>O>[Cl:8][C:6]1[N:7]=[CH:2][N:3]=[C:4]([N:13]2[CH2:14][CH:11]([OH:10])[CH2:12]2)[CH:5]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 775312,4-Dichloropyrimidine2회HCID 27592903-Hydroxyazetidine hydrochloride

생성물 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-ol수율 115.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

7.2 g (48.7 mmol) 2,4-dichloropyrimidine are initially introduced into 140 ml water. 5.3 g (48.7 mmol) 3-hydroxyazetidine hydrochloride and 48.7 ml 1 N sodium hydroxide solution are added and the mixture is heated at 90° C. for 72 h (the 2,4-dichloropyrimidine being detectably volatile and precipitating in crystalline form on the condenser). The solvent is removed in vacuo and the residue is dried to give 10.4 g of the crude product, which is reacted without further purification.

후처리

  1. customprecipitating in crystalline form on the condenser)
  2. customThe solvent is removed in vacuo
  3. customthe residue is dried

출처 및 근거

ORD 기록
ord-5b075ba59a9b4b8082cb1b5a68c371b8
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987261B2

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