Sulfuric acid magnesium salt (1:1) → 3-Bromothieno[2,3-b]pyridine

HRID 876784

반응식

HRID 876784 반응식
[Br:1]Br.[S:3]1[C:7]2=[N:8][CH:9]=[CH:10][CH:11]=[C:6]2[CH:5]=[CH:4]1.P([O-])([O-])(O)=O.[K+].[K+].C(=O)(O)[O-].[Na+].S([O-])([O-])(=O)=O.[Mg+2]>C(Cl)(Cl)Cl>[Br:1][C:5]1[C:6]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[S:3][CH:4]=1

참가 물질

7

반응물 5

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 24408BromineHCID 24450Potassium Phosphate, DibasicHCID 289928Thieno(2,3-b)pyridineHCID 516892Sodium Bicarbonate

생성물 1

HCID 2899263-Bromothieno[2,3-b]pyridine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Bromine (2.08 g, 13 mmol) was dropwise added to a mixture of thieno[2,3-b]pyridine (J-2) (1.35 g, 10 mmol), dipotassium monohydrogen orthophosphate (940 mg, 5.4 mmol), sodium bicarbonate (840 mg 10 mmol), and magnesium sulfate (2.0 g, 16.7 mmol) in chloroform (40 mL) which has been stirred at reflux for 16 h, the resulting mixture was stirred under reflux for 24 h, then filtered and washed with DCM. The filtrate was concentrated, and purified by chromatography. MS (m/z): 214 (M+H)+.

후처리

  1. temperatureat reflux for 16 h
  2. stirringthe resulting mixture was stirred
  3. temperatureunder reflux for 24 h
  4. filtrationfiltered
  5. washwashed with DCM
  6. concentrationThe filtrate was concentrated
  7. custompurified by chromatography

출처 및 근거

ORD 기록
ord-e6bddd748b86406bad8e56c13a380735
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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