Sodium borohydride → Thiazolo[4,5-c]pyridin-2-ylmethanol

HRID 876801노트

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HRID 876801 반응식
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]=[C:2]1[C:10](OCC)=[O:11].[BH4-].[Na+]>C(O)C>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]=[C:2]1[CH2:10][OH:11]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 65583458Ethyl thiazolo[4,5-c]pyridine-2-carboxylate

생성물 1

HCID 55296405Thiazolo[4,5-c]pyridin-2-ylmethanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl thiazolo[4,5-c]pyridine-2-carboxylate (R-3) (5 g, 24 mmol) in ethanol (100 mL) was added NaBH4 (0.9 g, 24 mmol) in portions at 0° C. The suspension was stirred at room temperature for 1 h, and then concentrated. The resulting residue was dissolved in EtOAc, washed with water. The organic layer was separated, dried over Na2SO4, concentrated in vacuo and purified by chromatography on silica gel to give the title compound. MS (m/z): 167 (M+1)+.

후처리

  1. concentrationconcentrated
  2. dissolutionThe resulting residue was dissolved in EtOAc
  3. washwashed with water
  4. customThe organic layer was separated
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. custompurified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-0e902d08eb0543d48737ba84b67a22d6
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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