Triethylamine → 2-(2,4-Dinitrophenoxy)-1H-isoindole-1,3(2H)-dione

HRID 876811

반응식

HRID 876811 반응식
[OH:1][N:2]1[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:12].CCN(CC)CC.Br[C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][C:22]=1[N+:30]([O-:32])=[O:31]>CC(C)=O>[N+:27]([C:24]1[CH:23]=[C:22]([N+:30]([O-:32])=[O:31])[CH:21]=[CH:26][C:25]=1[O:1][N:2]1[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:12])([O-:29])=[O:28]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 10665N-HydroxyphthalimideHCID 114411-Bromo-2,4-dinitrobenzene

생성물 1

HCID 70363092-(2,4-Dinitrophenoxy)-1H-isoindole-1,3(2H)-dione수율 96.4%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a suspension of 2-hydroxyisoindoline-1,3-dione (20.0 g, 0.12 mol) in acetone (400 mL) was added Et3N (14.9 g, 0.15 mol), the mixture was stirred at room temperature until it became a homogeneous solution, then 1-bromo-2,4-dinitrobenzene Y-1 (30.2 g, 0.12 mol) was added. The reaction was stirred at room temperature for 3 h, then poured into ice-water, the resulting precipitate was filtered and washed three times with cold MeOH, dried in vacuum to afford the title compound (38.1 g).

후처리

  1. stirringThe reaction was stirred at room temperature for 3 h
  2. filtrationthe resulting precipitate was filtered
  3. washwashed three times with cold MeOH
  4. customdried in vacuum

출처 및 근거

ORD 기록
ord-dbb3f970c0724ff3a7a479fecd60add1
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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