Chloroacetaldehyde → Imidazo[1,2-a]pyrazine-6-carbonitrile

HRID 876828노트

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HRID 876828 반응식
[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.Cl[CH2:11][CH:12]=O>C(O)C>[N:1]1[CH:11]=[CH:12][N:3]2[CH:4]=[C:5]([C:8]#[N:9])[N:6]=[CH:7][C:2]=12

참가 물질

4

반응물 2

HCID 33ChloroacetaldehydeHCID 139252945-Aminopyrazine-2-carbonitrile

생성물 1

HCID 67305172Imidazo[1,2-a]pyrazine-6-carbonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
110 °C

실험 절차

To a solution of 5-aminopyrazine-2-carbonitrile (5-1) (350 mg, 2.92 mmol) in ethanol (15 mL) was added 2-chloroacetaldehyde (4 mL, 40% in water). The mixture was stirred at 110° C. overnight. The solution was concentrated, then purified by chromatography on silica gel to afford the title compound (280 mg). MS (m/z): 145.1 (M+H)+.

후처리

  1. concentrationThe solution was concentrated
  2. custompurified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-23c0b6e5566b4dfdb18ef6d736ea099a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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