Ammonia → HCID 67313715, 화합물

HRID 876829노트

반응식

HRID 876829 반응식
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([C:10]#[N:11])[N:7]=[CH:6][C:5]=12.N>CO.[Ni]>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH2:10][NH2:11])[N:7]=[CH:6][C:5]=12

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 67305172Imidazo[1,2-a]pyrazine-6-carbonitrile

생성물 1

HCID 67313715HCID 67313715, 화합물수율 86.4%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

To a solution of imidazo[1,2-a]pyrazine-6-carbonitrile (5-1) (180 mg, 1.25 mmol) in methanol (15 mL) were added Raney nickel (slurry in water, 150 mg) and 1 N ammonia. The reaction mixture was stirred under H2 (1 atm) for 2 h. The mixture was filtered, and the filtrate was concentrated to afford the title compound (160 mg). MS (m/z): 149.1 (M+H)+

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-267c4356450e4b0ea3ed6c4cd2c54e6d
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987269B2

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