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Formaldehyde → 2-(4-(1-((3-(Hydroxymethyl)imidazo[1,2-a]pyridin-6-yl)methyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol

HRID 876860
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HRID 876860 반응식
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][N:11]2[C:15]3=[N:16][C:17]([C:20]4[CH:21]=[N:22][N:23](C)[CH:24]=4)=[CH:18][N:19]=[C:14]3[N:13]=[N:12]2)=[CH:2]1.[C:26]([O-])(=O)[CH3:27].[Na+].[CH2:31]=[O:32].[OH-:33].[Na+]>C(O)(=O)C>[OH:32][CH2:31][C:8]1[N:1]2[CH:2]=[C:3]([CH2:10][N:11]3[C:15]4=[N:16][C:17]([C:20]5[CH:24]=[N:23][N:22]([CH2:26][CH2:27][OH:33])[CH:21]=5)=[CH:18][N:19]=[C:14]4[N:13]=[N:12]3)[CH:9]=[CH:4][C:5]2=[N:6][CH:7]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 517045Sodium AcetateHCID 673059931-((1H-Pyrrolo[2,3-b]pyridin-3-yl)methyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]-triazolo[4,5-b]pyrazine

생성물 1

HCID 673061182-(4-(1-((3-(Hydroxymethyl)imidazo[1,2-a]pyridin-6-yl)methyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
100 °C

실험 절차

To a solution of 306-a (60 mg, 0.13 mmol) (prepared according to the procedure of Compound 1) in 0.1 mL of acetic acid were added sodium acetate (39 mg, 0.48 mmol) and then formaldehyde (0.13 mL, 37% in water). The mixture was stirred at 100° C. overnight. After cooled, the mixture was adjusted to pH>7 with aqueous NaOH. The resulting precipitate was collected and purified by chromatography to afford the title compound (10 mg). MS (m/z): 392.0 (M+H)+

후처리

  1. temperatureAfter cooled
  2. customThe resulting precipitate was collected
  3. custompurified by chromatography

출처 및 근거

ORD 기록
ord-3b360b11de2247fda03242f9fed19b93
출처 데이터셋
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08987269B2

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