Formamide → 5,6-Difluoroisoindoline-1,3-dione

반응식

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][C:12]=1[F:13].C([NH2:16])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:11][C:12]=1[F:13])[C:6](=[O:7])[NH:16][C:9]2=[O:8]

참가 물질

반응물 2

HCID 713Formamide

HCID 6397454,5-Difluorophthalic Anhydride

생성물 1

HCID 148182125,6-Difluoroisoindoline-1,3-dione

실험 절차

At 130° C., 1.0 g (5.4 mmol) of 4,5-difluorophthalic anhydride was stirred in 6 ml of formamide for 2 h. After cooling, the reaction mixture was then added to ice-cold water. The precipitated yellow solid was filtered off with suction, washed thoroughly with cold water and dried under high vacuum. This gave 744 mg of a white solid (74.8% of theory).

후처리

temperatureAfter cooling
additionthe reaction mixture was then added to ice-cold water
filtrationThe precipitated yellow solid was filtered off with suction
washwashed thoroughly with cold water
customdried under high vacuum

출처 및 근거

ORD 기록: ord-202235d35c12483ab53dba07875fb838
출처 데이터셋: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08987256B2

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