Sodium Hydroxide → HCID 44513409, 화합물

HRID 877270노트

반응식

HRID 877270 반응식
[CH3:1][CH:2]([CH2:40][CH3:41])[CH:3]([C:20]1[CH:25]=[CH:24][C:23]([CH2:26][N:27]2[C:32](=[O:33])[CH2:31][O:30][C:29]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[N:28]2)=[CH:22][CH:21]=1)[C:4]([NH:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH2:9][CH:10]([C:16]([O:18]C)=[O:17])[CH2:11]2)=[O:5].[OH-].[Na+]>C1COCC1>[CH3:1][CH:2]([CH2:40][CH3:41])[CH:3]([C:20]1[CH:25]=[CH:24][C:23]([CH2:26][N:27]2[C:32](=[O:33])[CH2:31][O:30][C:29]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)=[N:28]2)=[CH:22][CH:21]=1)[C:4]([NH:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH2:9][CH:10]([C:16]([OH:18])=[O:17])[CH2:11]2)=[O:5]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 58136310HCID 58136310, 화합물

생성물 1

HCID 44513409HCID 44513409, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 180 mg (0.31 mmol) of methyl 4-[(3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}pentanoyl)amino]-2,3-dihydro-1H-indene-2-carboxylate (Example 147A) in 3.6 ml of THF and 1.3 ml (1.3 mmol) of 1 N aqueous sodium hydroxide solution was stirred at room temperature overnight. After the reaction had gone to completion, the THF was removed under reduced pressure and the reaction solution was diluted with water and then adjusted to pH 2 with 1 M hydrochloric acid. The precipitated solid was filtered off, washed with water and dried under reduced pressure at 45° C. overnight. This gave 159 mg (0.29 mmol, 91% of theory) of the title compound as a mixture of isomers.

후처리

  1. customthe THF was removed under reduced pressure
  2. additionthe reaction solution was diluted with water
  3. filtrationThe precipitated solid was filtered off
  4. washwashed with water
  5. customdried under reduced pressure at 45° C. overnight
  6. additionThis gave 159 mg (0.29 mmol, 91% of theory) of the title compound as a mixture of isomers

출처 및 근거

ORD 기록
ord-506cd3df9af64af2991b691e4d02a149
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987256B2

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