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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → (S)-[1-(2-methoxy-1,1-dimethyl-2-oxoethyl)-1H-1,2,3-triazol-4-yl][4-(2,2,2-trifluoroethoxy)phenyl]methanaminium chloride

HRID 877359
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HRID 877359 반응식
C(S([NH:7][C@H:8]([C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]([F:32])([F:31])[F:30])=CN=1)[C:9]1[N:10]=[N:11][N:12]([C:14]([CH3:20])([CH3:19])[C:15]([O:17][CH3:18])=[O:16])[CH:13]=1)=O)(C)(C)C.[ClH:33].[CH2:34](OCC)[CH3:35]>CO>[Cl-:33].[CH3:18][O:17][C:15](=[O:16])[C:14]([N:12]1[CH:13]=[C:9]([C@H:8]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]([F:31])([F:30])[F:32])=[CH:35][CH:34]=2)[NH3+:7])[N:10]=[N:11]1)([CH3:19])[CH3:20]
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참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 67174474methyl 2-(4-{(S)-[(tert-butylsulfinyl)amino][5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}-1H-1,2,3-triazol-1-yl)-2-methylpropanoate

생성물 1

HCID 86668960(S)-[1-(2-methoxy-1,1-dimethyl-2-oxoethyl)-1H-1,2,3-triazol-4-yl][4-(2,2,2-trifluoroethoxy)phenyl]methanaminium chloride

시약·촉매·용매 1

HCID 887
Methanol
용매

실험 절차

To a solution of 0.12 g (0.25 mmol) methyl 2-(4-{(S)-[(tert-butylsulfinyl)amino][5-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}-1H-1,2,3-triazol-1-yl)-2-methylpropanoate in 1.0 ml MeOH was added 0.96 mL (1.9 mmol) 2.0M HCl in diethyl ether. After 30 min at room temperature, the reaction mixture was concentrated in vacuo to afford (S)-[1-(2-methoxy-1,1-dimethyl-2-oxoethyl)-1H-1,2,3-triazol-4-yl][4-(2,2,2-trifluoroethoxy)phenyl]methanaminium chloride. ES-MS [M+1]+=374.1.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-f0407006be5447f0a2ddb53664021e1a
출처 데이터셋
uspto-grants-2015_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08987310B2

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