Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → HCID 60197099, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Chloro-4-fluorobenzoyl Chloride | HCID 2736548 | — |
| 반응물 | N-methyl-4-o-tolylpyridin-3-amine | HCID 18403336 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 60197099 | HCID 60197099 | 29% |
반응 단계
3-Chloro-4-fluorobenzoyl chloride (60 mg, 0.31 mmol, CAS RN 65055-17-6) was added to a solution of methyl-(4-o-tolyl-pyridin-3-yl)-amine (45 mg, 0.23 mmol, example 1, intermediate a) and DIPEA (79 μL, 0.45 mmol) in CH2Cl2 (1 mL). The reaction mixture was stirred overnight and then loaded directly onto a silica gel column and eluted with 50% EtOAc in n-hexane to yield the product as a waxy solid (23 mg, 29%). MS (ESI): m/z=355.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08987307B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-3d1e2f56dcde4ff895a1a1fa88d547c7 |
| 출처 메모 | uspto-grants-2015_03 |