Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Fluoro-2-methylphenylboronic acid → 6-chloro-4-(5-fluoro-2-methylphenyl)-N-methylpyridin-3-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Fluoro-2-methylphenylboronic acid | HCID 2783190 | — |
| 반응물 | 6-Chloro-4-iodo-N-methylpyridin-3-amine | HCID 57443400 | — |
| 생성물 | 6-chloro-4-(5-fluoro-2-methylphenyl)-N-methylpyridin-3-amine | HCID 57710450 | — |
반응 단계
The title compound was prepared in analogy to example 72, from 6-chloro-4-iodo-N-methylpyridin-3-amine (prepared according to WO2006013050) and 5-fluoro-2-methylphenylboronic acid after heating at reflux for 21 hours. The compound was purified by silica gel chromatography on a 50 g column using an MPLC system eluting with a gradient of n-heptane:EtOAc (100:0 to 50:50). Light brown solid (85%). MS (ESI): m/z=251.08 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08987307B2 |
| 출처 데이터셋 | uspto-grants-2015_03 |
| ORD ID | ord-8a33777f3ae042c4b4ae8e72cd139589 |
| 출처 메모 | uspto-grants-2015_03 |