Phenylboronic Acid → 2-Chloro-6-phenylpyrazine

HRID 878448

반응식

HRID 878448 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[C:9]1(B(O)O)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1

참가 물질

3

반응물 2

HCID 66827Phenylboronic AcidHCID 785042,6-Dichloropyrazine

생성물 1

HCID 52160922-Chloro-6-phenylpyrazine

실험 절차

Prepared from 2,6-dichloropyrazine (1.01 g, 6.78 mmol) and phenylboronic acid (946.7 mg, 7.76 mmol) according to Method K, except the product was purified by silica gel chromatography (DCM, Rf=0.37) instead of preparative HPLC: 1H NMR (300 MHz, chloroform-D) δ ppm 7.46-7.53 (m, 3H), 7.94-7.98 (m, 2H), 8.22 (s, 1H), 8.63 (s, 1H). MS (DCI/NH3) m/z=191 (M+H)+.

후처리

  1. customwas purified by silica gel chromatography (DCM, Rf=0.37) instead of preparative HPLC

출처 및 근거

ORD 기록
ord-897a0f18debb4261b231167c27d39f23
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987453B2

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