2,4-Difluoroacetophenone → 1-(2,4-Difluorophenyl)-3-(dimethylamino)prop-2-en-1-one

HRID 878501노트

반응식

HRID 878501 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[CH3:12][N:13]([CH:15](OC)OC)[CH3:14]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])/[CH:10]=[CH:12]/[N:13]([CH3:15])[CH3:14]

참가 물질

3

반응물 2

HCID 677702,4-DifluoroacetophenoneHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 57140271-(2,4-Difluorophenyl)-3-(dimethylamino)prop-2-en-1-one수율 82%

실험 절차

The title compound was prepared in 82% yield from 1-(2,4-difluorophenyl)ethanone and DMF-DMA according to the procedure for the preparation of Example 12, part A. 1H NMR (400 MHz, CDCl3): δ 2.90 (3H, s), 3.11(3H, s), 5.59-5.62 (1H, m), 6.77-6.83 (1H, m), 6.88-6.93 (m, 1H), 7.75-7.83 (2H, m).

출처 및 근거

ORD 기록
ord-4e62d7f6a9374c81b6e736e580ec4021
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987461B2

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