Potassium bisulfate → 4-{[tert-Butyl(dimethyl)silyl]oxy}butanoic acid

HRID 878621노트

반응식

HRID 878621 반응식
[Si:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]([O:14][Li])=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].OS([O-])(=O)=O.[K+]>C(OCC)(=O)C>[Si:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 516920Potassium bisulfateHCID 178506949HCID 178506949, 화합물

생성물 1

HCID 1868234-{[tert-Butyl(dimethyl)silyl]oxy}butanoic acid수율 95%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 4-[tert-butyl(dimethyl)silyl]oxybutanoyloxylithium (8.0 g, 35.71 mmol) in ethyl acetate (10 mL), was carefully added KHSO4 (5%) to adjust pH to about 1. It was then extracted with ethyl acetate three times and organic extracts washed with brine and dried with anhydrous NaSO4. The organic extracts were concentrated to give the title compound (7.4 g, 95%). [M+H] Calc'd for C10H22O3Si, 219; Found, 219.

후처리

  1. extractionIt was then extracted with ethyl acetate three times and organic extracts
  2. washwashed with brine
  3. dry with materialdried with anhydrous NaSO4
  4. concentrationThe organic extracts were concentrated

출처 및 근거

ORD 기록
ord-6031e919e9a34a09947d5a51c04406eb
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987461B2

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