Hydrogen Peroxide → 2,3-Epoxy-2-methyl-1,4-naphthoquinone

HRID 879020

반응식

HRID 879020 반응식
[CH3:1][C:2]1[C:12](=[O:13])[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:4](=[O:5])[CH:3]=1.[OH-:14].[Na+].OO>CO.O>[CH3:1][C:2]12[C:12](=[O:13])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4](=[O:5])[CH:3]1[O:14]2

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 4055MenadioneHCID 14798Sodium Hydroxide

생성물 1

HCID 858452,3-Epoxy-2-methyl-1,4-naphthoquinone수율 91.5%

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

Menadione crystalline (1) (5 g, 29.04 mmol, 1 equivalent) and 2 M NaOH (7.26 mL, 14.52 mmol, 0.5 equivalents) are dissolved in a mixture of methanol/water 4:1 (50 mL) at 0-2° C. After stirring at this temperature for 10 minutes, 35% hydrogen peroxide is added (4.2 mL, 43.56 mmol, 1.5 equivalents). Work-up: after 30 minutes at 0° C. the product is extracted with ethyl ether. The organic phase is dried over Na2SO4 and evaporated under reduced pressure. A whitish powder is obtained (5 g, 26.57 mmol). Yield: 91.5%.

후처리

  1. extractionafter 30 minutes at 0° C. the product is extracted with ethyl ether
  2. dry with materialThe organic phase is dried over Na2SO4
  3. customevaporated under reduced pressure
  4. customA whitish powder is obtained (5 g, 26.57 mmol)

출처 및 근거

ORD 기록
ord-a7e61bb52da04aeb97d2f2e8f4e6d445
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08987503B2

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