Ethanolamine → HCID 66914997, 화합물

HRID 880406

반응식

HRID 880406 반응식
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH2:10]([CH2:12][NH2:13])[OH:11].[OH-].[Na+]>O.O1CCOCC1>[CH3:8][C:6]1[CH:5]=[C:4]([CH3:9])[N:3]=[C:2]([O:11][CH2:10][CH2:12][NH2:13])[CH:7]=1

참가 물질

6

반응물 3

HCID 700EthanolamineHCID 14798Sodium HydroxideHCID 125083782-Chloro-4,6-dimethylpyridine

생성물 1

HCID 66914997HCID 66914997, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

From 2-chloro-4,6-dimethylpyridine by treatment with ethanolamine and sodium hydroxide in a mixture of water and dioxane to afford 2-(4,6-dimethyl-pyridin-2-yloxy)-ethylamine, followed by heating with 1-fluoro-4-nitrobenzene in ethanol to give [2-(4,6-dimethyl-pyridin-2-yloxy)-ethyl]-(4-nitro-phenyl)-amine. The free amine is protected as a trifluoroacetamide by treatment with trifluoroacetic anhydride and sodium hydride in THF then the nitro group is reduced with zinc powder in the presence of ammonium chloride in ethanol. Following coupling with the appropriately-selected acid chloride, a final treatment with lithium hydroxide in methanol removes the trifluoroacetamide to give the final compound described.

출처 및 근거

ORD 기록
ord-670e8ae524cb41b8b6ebd2e9f88f5142
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993574B2

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