Sodium Hydroxide → 4-phenyl-1H-pyrrole-2-carboxylic acid

HRID 880432노트

반응식

HRID 880432 반응식
[C:1]1([C:7]2[CH:8]=[C:9]([C:12]([O:14]CC)=[O:13])[NH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([C:7]2[CH:8]=[C:9]([C:12]([OH:14])=[O:13])[NH:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 14643813Ethyl 4-phenyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 128971004-phenyl-1H-pyrrole-2-carboxylic acid수율 66%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of ethyl 4-phenyl-1H-pyrrole-2-carboxylate (700 mg, 3.25 mmol), aqueous sodium hydroxide (10% w/v, 10 mL) and ethanol (10 mL) were stirred at room temperature over night. The ethanol was evaporated in vacuo, then water (20 mL) was added and the organics were extracted with ethyl acetate (3×20 mL). The aqueous layer was acidified with 2N HCl (to pH 3) and extracted with ethyl acetate (3×20 mL). The combined organic layer was washed with water, brine (20 mL), dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 4-phenyl-1H-pyrrole-2-carboxylic acid (400 mg, 66%) as a solid.

후처리

  1. customThe ethanol was evaporated in vacuo
  2. additionwater (20 mL) was added
  3. extractionthe organics were extracted with ethyl acetate (3×20 mL)
  4. extractionextracted with ethyl acetate (3×20 mL)
  5. washThe combined organic layer was washed with water, brine (20 mL)
  6. dry with materialdried over anhydrous sodium sulphate
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6d3e196acd714c4690d354282c61aa0e
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993574B2

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