1-Methylpiperazine → 1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

HRID 880526

반응식

HRID 880526 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO.O>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[C:11]([F:14])([F:13])[F:12])[CH2:18][CH2:17]1

참가 물질

5

반응물 2

HCID 531671-MethylpiperazineHCID 949542-Fluoro-5-nitrobenzotrifluoride

생성물 1

HCID 31280181-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

2-Fluoro-5-nitrobenzotrifluoride (2 g) and 1-methylpiperazine (2 mL) were dissolved in methanol (5 mL). The yellow solution was stirred at rt overnight. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic solutions were evaporated to give 2-(4-methyl piperazino)-5-nitrobenzotrifluoride.

후처리

  1. extractionextracted with ethyl acetate (2×100 mL)
  2. customThe organic solutions were evaporated

출처 및 근거

ORD 기록
ord-af62b20c91344c588c1bbd718304438a
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993585B2

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