Acetic Acid → 4-Bromo-2-chloro-6-(trifluoromethyl)aniline

HRID 880655

반응식

HRID 880655 반응식
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[C:11]=1[NH2:12].C(O)(=O)C>C(#N)C>[Br:1][C:15]1[CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[C:11]([NH2:12])=[C:10]([Cl:9])[CH:16]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 67184N-bromobutanimideHCID 27563842-Chloro-6-(trifluoromethyl)aniline

생성물 1

HCID 162179374-Bromo-2-chloro-6-(trifluoromethyl)aniline

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N-bromo succinimide (910 mg, 5.1 mmol) was added to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL) at room temperature. The mixture was heated at reflux, with stirring, for 18 h. The reaction mixture was then filtered through Celite and concentrated to give the title compound, which was used in the next step without further purification.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux
  3. filtrationThe reaction mixture was then filtered through Celite
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-62cbed9771e744a78af50d42da7422b1
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993593B2

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