Acetic Acid → 4-Bromo-2-chloro-6-(trifluoromethyl)aniline

HRID 880657

반응식

HRID 880657 반응식
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[C:11]=1[NH2:12].C(O)(=O)C>C(#N)C>[Br:1][C:15]1[CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[C:11]([NH2:12])=[C:10]([Cl:9])[CH:16]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 67184N-bromobutanimideHCID 27563842-Chloro-6-(trifluoromethyl)aniline

생성물 1

HCID 162179374-Bromo-2-chloro-6-(trifluoromethyl)aniline

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N-bromosuccinimide (910 mg, 5.1 mmol) was added to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL) at room temperature. The mixture was stirred at reflux for 18 h. The reaction mixture was then filtered through Celite and concentrated to give the title compound, which was used in the next step without further purification.

후처리

  1. temperatureat reflux for 18 h
  2. filtrationThe reaction mixture was then filtered through Celite
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e3798e5b36fd4ff7905c6b2482a0d644
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993593B2

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