Water → HCID 178494417, 화합물
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[CH3:1][O:2][C:3]1([OH:20])[CH:8]=[C:7]([O:9]C)[N:6]=[C:5]([C:11]2[S:12][CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:15]=2)[NH:4]1.B(Cl)(Cl)Cl.O.C(Cl)Cl>ClCCCl>[OH:9][C:7]1[N:6]=[C:5]([C:11]2[S:12][CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[N:15]=2)[NH:4][C:3]([O:2][CH3:1])([OH:20])[CH:8]=1참가 물질
6
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- 온도
- 60 °C
실험 절차
To a solution of compound 288 (460 mg, 1 eq.) in DCE (10 mL) was added BCl3 (3.16 mL, 2 eq.). The mixture was stirred at 60° C. for 16 hrs. Water and DCM were then added. Organics were separated, dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was triturated in a DCM/pentane mixture to yield compound 289 as a beige solid in 38% yield. MS (ESI, EI+): m/z=278 (MH+).
후처리
- customOrganics were separated
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
- customThe residue was triturated in a DCM/pentane mixture
출처 및 근거
- ORD 기록
- ord-fa3f17e7b15c4c2ebadec2cfd1a6771a
- 출처 데이터셋
- uspto-grants-2015_03
- 특허 번호
- US08993595B2
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