Hydrochloric Acid → HCID 178497304, 화합물

HRID 880969노트

반응식

HRID 880969 반응식
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[NH:4][NH:3]1.Cl.[CH3:15]O>>[OH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13][CH3:15])=[O:12])=[CH:8][CH:9]=2)[NH:4][N:3]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 533377172,3-Dihydro-3-oxo-1H-indazole-6-carboxylic acid

생성물 1

HCID 178497304HCID 178497304, 화합물수율 100%

실험 절차

3-Oxo-2,3-dihydro-1H-indazole-6-carboxylic acid (1.5 g, 8.4 mmol) was suspended in methanol (17 mL). Concentrated hydrochloric acid (3.1 mL, 101 mmol) was added and the reaction was heated to reflux for 24 hours. The reaction was concentrated to give the title compound (1.6 g, 100%). +ESI (M+H) 193.1; 1H NMR (400 MHz, DMSO-d6, δ): 11.98 (br. s., 1H), 7.89 (s, 1H), 7.72 (d, J=8.6 Hz, 1H), 7.50 (dd, J=8.5, 1.3 Hz, 1H), 3.85 (s, 3H).

후처리

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 24 hours
  3. concentrationThe reaction was concentrated

출처 및 근거

ORD 기록
ord-8752cf31145749909a2bac67fe6bd245
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993586B2

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