1,7-Diphenyl-4-heptanol → HCID 178418375, 화합물

HRID 882

반응식

HRID 882 반응식
[Si:1]([O:8][C@H:9]1[CH2:14][CH2:13][C@H:12](/[CH:15]=[C:16](\[CH3:19])/[CH:17]=[O:18])[CH2:11][CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:20]1([CH2:26][CH2:27][CH2:28][Mg]Br)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C1(CCCC(O)CCCC2C=CC=CC=2)C=CC=CC=1>C1COCC1>[Si:1]([O:8][C@H:9]1[CH2:10][CH2:11][C@H:12](/[CH:15]=[C:16](\[CH3:19])/[CH:17]([OH:18])[CH2:28][CH2:27][CH2:26][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:13][CH2:14]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 105398701,7-Diphenyl-4-heptanolHCID 178418459HCID 178418459, 화합물HCID 178418471HCID 178418471, 화합물

생성물 1

HCID 178418375HCID 178418375, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The alcohol 137 was prepared from the crude aldehyde 136. and 1.5 mL (0.75 mmol) of 120 in 2.0 mL of THF as described above for the synthesis of alcohol 121 in Example 1 to give 220 mg of the crude diastereomeric alcohol 137. Flash chromatography (elution with 20% ethyl acetate in hexane) afforded 146 mg of the alcohol 137 as an oil. 1H NMR consistent with structure.

출처 및 근거

ORD 기록
ord-a6be5895ebf2488a874923e3878acfbe
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723459

연결된 노트

불러오는 중…