Hydrochloric Acid → HCID 66629751, 화합물

HRID 882336노트

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HRID 882336 반응식
[ClH:1].[C:2]1([C@@H:8]2[CH2:10][C@H:9]2[NH:11][CH2:12][C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOCC>[ClH:1].[C:2]1([C@@H:8]2[CH2:10][C@H:9]2[NH:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:17]#[N:18])=[CH:19][CH:20]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 46869800HCID 46869800, 화합물

생성물 1

HCID 66629751HCID 66629751, 화합물수율 84.5%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
-78 °C

실험 절차

2 M ethereal solution of HCl (0.14 mL, 0.27 mmol) was slowly added to a solution of 4-({[(trans)-2-phenylcyclopropyl]amino}methyl)benzonitrile (67 mg, 0.27 mmol) in dry Et2O (5 mL) cooled at −78° C., and allowed to reach room temperature. After 10 min the white precipitate was allowed to settle and Et2O was decanted, the solid was washed with Et2O (20 mL) and vacuum dried, rendering 65 mg of 4-({[(trans)-2-phenylcyclopropyl]amino}methyl)benzonitrile hydrochloride (white solid, 84% yield).

후처리

  1. customto reach room temperature
  2. customEt2O was decanted
  3. washthe solid was washed with Et2O (20 mL) and vacuum
  4. customdried

출처 및 근거

ORD 기록
ord-9fa84ba054ce4cf3815844a8ffbcbb36
출처 데이터셋
uspto-grants-2015_03
특허 번호
US08993808B2

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