Hydrochloric Acid → 2-Methyl-1,3-benzoxazole-4-carboxylic acid

HRID 882791

반응식

HRID 882791 반응식
[OH-].[K+].C([O:5][C:6]([C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[O:16][C:15]([CH3:17])=[N:14][C:13]=12)=[O:7])C.Cl>CO>[CH3:17][C:15]1[O:16][C:12]2[C:13](=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[CH:10][CH:11]=2)[N:14]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 593168402-Methyl-benzooxazole-4-carboxylic acid ethyl ester

생성물 1

HCID 183546282-Methyl-1,3-benzoxazole-4-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

At 0° C. an aq. KOH solution (1.0M, 2.40 mL) is added to a solution of 2-methyl-benzooxazole-4-carboxylic acid ethyl ester (0.98 mmol) in MeOH (5.0 mL) and stirred for 30 min. The mixture is allowed to reach rt, stirred for additional 60 min and made acidic by addition of aq. hydrochloric acid (2.0 M). After removal of MeOH under reduced pressure the obtained precipitate is filtered off to give the desired product which is dried in vacuo. 1H-NMR (DMSO-d6): δ=2.64 (s, 3H); 7.41 (t, J=8.0 Hz, 1H); 7.83 (d, J=7.8 Hz, 1H); 7.88 (d, J=8.0 Hz, 1H); 12.8 (bs, 1H).

후처리

  1. customto reach rt
  2. stirringstirred for additional 60 min
  3. customAfter removal of MeOH under reduced pressure the obtained precipitate
  4. filtrationis filtered off

출처 및 근거

ORD 기록
ord-bd690755fa9d4336a93624b3eb6a4a31
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236801B2

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