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Potassium Carbonate → (1R,3S,4S)-3-[(5-Bromo-pyrimidin-2-ylamino)-methyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

HRID 882800
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HRID 882800 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[C:9]([O:13][C:14]([N:16]1[C@H:21]([CH2:22][NH2:23])[C@@H:20]2[CH2:24][C@H:17]1[CH2:18][CH2:19]2)=[O:15])([CH3:12])([CH3:11])[CH3:10].C([O-])([O-])=O.[K+].[K+].CCN(C(C)C)C(C)C>CC1C=CC=CC=1C>[C:9]([O:13][C:14]([N:16]1[C@H:21]([CH2:22][NH:23][C:5]2[N:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]=2)[C@@H:20]2[CH2:24][C@H:17]1[CH2:18][CH2:19]2)=[O:15])([CH3:12])([CH3:10])[CH3:11]
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6

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HCID 11430Potassium CarbonateHCID 81531DiisopropylethylamineHCID 6066655-Bromo-2-chloropyrimidineHCID 66866957tert-butyl (1R,3S,4S)-3-(aminomethyl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

생성물 1

HCID 66867454(1R,3S,4S)-3-[(5-Bromo-pyrimidin-2-ylamino)-methyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

시약·촉매·용매 1

HCID 7237O-Xylene용매

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온도
138 °C

실험 절차

5-Bromo-2-chloro-pyrimidine (8.62 mmol) is added to a solution of (1R,3S,4S)-3-aminomethyl-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (6.63 mmol) in o-xylene (25 mL). K2CO3 (20.0 mmol) and DIPEA (19.9 mmol) are added successively and the mixture is heated to 138° C. for 16 h. The mixture is cooled to rt and filtered. The residue is washed with DCM and the combined filtrates are concentrated in vacuo to give the desired product which is used without further purification. LC-MS: tR=1.09 min; [M+H]+=383.3.

후처리

  1. temperatureThe mixture is cooled to rt
  2. filtrationfiltered
  3. washThe residue is washed with DCM
  4. concentrationthe combined filtrates are concentrated in vacuo

출처 및 근거

ORD 기록
ord-a91eae23f64341bb91499d271d16dbf5
출처 데이터셋
uspto-grants-2012_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08236801B2

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