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Hydrazine hydrate (1:1) → HCID 86656622, 화합물

HRID 882885
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HRID 882885 반응식
[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]([CH2:12][N:13]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:9][CH2:10][CH3:11])([CH3:4])([CH3:3])[CH3:2].O.NN>CCO.C(Cl)Cl>[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]([CH2:12][NH2:13])[CH2:9][CH2:10][CH3:11])([CH3:2])([CH3:3])[CH3:4]
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참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 67029019[(R)-1-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester

생성물 1

HCID 86656622HCID 86656622, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

A mixture of [(R)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester (1.2 g, 3.61 mmol) and hydrazine monohydrate (1.0 mL, 20.6 mmol) in EtOH (25 mL) and DCM (75 mL) is stirred at RT for 48 h. The precipitated solid is removed by filtration and washed with DCM. The filtrate is concentrated in vacuo to afford the title compound as white solid that is used without further purification.

후처리

  1. customThe precipitated solid is removed by filtration
  2. washwashed with DCM
  3. concentrationThe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-6a54d8b8460a4f38b414beb8347ad849
출처 데이터셋
uspto-grants-2012_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08236808B2

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