Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate → 3,5-Diamino-N-(2-aminoethyl)-6-chloropyrazine-2-carboxamide

HRID 882916노트

반응식

HRID 882916 반응식
CO[C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([NH2:12])=[C:7]([Cl:13])[N:6]=1)=[O:4]>C(N)CN>[NH2:6][CH2:5][CH2:10][NH:9][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8]([NH2:12])=[C:7]([Cl:13])[N:6]=1)=[O:4]

참가 물질

3

반응물 1

HCID 73827Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

생성물 1

HCID 151481293,5-Diamino-N-(2-aminoethyl)-6-chloropyrazine-2-carboxamide

시약·촉매·용매 1

HCID 3301Ethylenediamine용매

반응 조건

온도
0 °C

실험 절차

3,5-Diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester (2.0 g, 9.88 mmol) in neat ethylene diamine (18 mL) is heated using microwave irradiation in a Personal Chemistry Emrys™ Optimizer microwave reactor at 130° C. for 1 h at 4 bar. The solvent is removed in vacuo, water (10 mL) is added to the orange solid and the suspension is then cooled to 0° C. The off-white solid is collected by filtration and dried under vacuum at 50° C. to afford the title compound. [M+H]+ 231.

후처리

  1. custommicrowave irradiation in a Personal Chemistry Emrys™ Optimizer microwave reactor at 130° C. for 1 h at 4 bar
  2. customThe solvent is removed in vacuo, water (10 mL)
  3. additionis added to the orange solid
  4. filtrationThe off-white solid is collected by filtration
  5. customdried under vacuum at 50° C.

출처 및 근거

ORD 기록
ord-cd5b8818661e4958ba6bbc5a3134d833
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236808B2

반응 노트

불러오는 중…