Triethylamine → 2-Chloro-1-ethoxy-4-isocyanatobenzene

HRID 882921노트

반응식

HRID 882921 반응식
C(N(CC)CC)C.[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=1[Cl:18])[CH3:9].Cl[C:20](Cl)([O:22]C(=O)OC(Cl)(Cl)Cl)Cl>CCOC(C)=O>[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[C:20]=[O:22])=[CH:13][C:12]=1[Cl:18])[CH3:9]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 94429TriphosgeneHCID 127487363-Chloro-4-ethoxyaniline

생성물 1

HCID 30159672-Chloro-1-ethoxy-4-isocyanatobenzene

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

1-Ethoxy-2-chloro-4-isocyanato-benzene is prepared by addition of triethylamine to a solution of 4-ethoxy-3-chlorophenylamine in EtOAc at 0-5° C. Triphosgene is added and the reaction mixture is slowly heated to reflux over 2 h. The solvent is removed in vacuo and the crude product is filtered through silica to afford the title compound.

후처리

  1. temperaturethe reaction mixture is slowly heated
  2. temperatureto reflux over 2 h
  3. customThe solvent is removed in vacuo
  4. filtrationthe crude product is filtered through silica

출처 및 근거

ORD 기록
ord-ae35c798b7ed4080a800857f520a5976
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236808B2

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