Nitric Acid → 4-Bromo-7-hydroxy-6-nitro-2,3-dihydro-1H-inden-1-one
반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12].C(OC(=O)C)(=O)C.[N+:20]([O-])([OH:22])=[O:21]>C(O)(=O)C>[Br:1][C:2]1[CH:10]=[C:9]([N+:20]([O-:22])=[O:21])[C:8]([OH:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:12]참가 물질
5
실험 절차
4-Bromo-7-hydroxyindan-1-one (3.06 g, 13.5 mmol) was suspended in acetic acid (20 mL), and acetic anhydride (1.66 mL, 17.6 mmol) and fuming nitric acid (838 μL, 20.2 mmol) dissolved in acetic acid (10 mL) were added. The mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure and the precipitated yellow crystals were collected by filtration to give the title compound (2.98 g, yield 79%).
후처리
- additionwere added
- customThe solvent was evaporated under reduced pressure
- filtrationthe precipitated yellow crystals were collected by filtration
출처 및 근거
- ORD 기록
- ord-13bb3efcd7fd450bb282932202cdd711
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08236837B2
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