Ethanol → 3-(3-Methoxypropyl)-2-thioxanthine

HRID 883550노트

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HRID 883550 반응식
[NH2:1][C:2]1[C:3](=[O:17])[NH:4][C:5](=[S:16])[N:6]([CH2:9][CH:10]2CCCC[CH2:11]2)[C:7]=1[NH2:8].[CH:18](OCC)(OCC)[O:19]CC.[CH2:28](O)C>>[CH3:18][O:19][CH2:11][CH2:10][CH2:9][N:6]1[C:7]2[N:8]=[CH:28][NH:1][C:2]=2[C:3](=[O:17])[NH:4][C:5]1=[S:16]

참가 물질

4

반응물 3

HCID 702EthanolHCID 31214Ethyl orthoformateHCID 86601053HCID 86601053, 화합물

생성물 1

HCID 103542623-(3-Methoxypropyl)-2-thioxanthine수율 9%

실험 절차

5,6-Diamino-1-cyclohexylmethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (1.6 g, 12.2 mmol) was dissolved in ethanol (10 mL) and triethyl orthoformate (10 mL) and the reaction mixture was refluxed for 2.5 h. The solvents were evaporated off and the resulting brown solid was purified by flash chromatography (heptane/ethyl acetate, 4:1-1:1) to give the title compound (110 mg, 9%).

후처리

  1. customThe solvents were evaporated off
  2. customthe resulting brown solid was purified by flash chromatography (heptane/ethyl acetate, 4:1-1:1)

출처 및 근거

ORD 기록
ord-bab2a1909e9c4c839b29f24efb4f6a4e
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236951B2

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