Hydrochloric Acid → 6-Amino-1-isobutyl-3-methyl-5-nitroso-2-thioxo-1H-pyrimidin-4-one
반응식
[N:1]([O-:3])=O.[Na+].[NH2:5][C:6]1[N:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[C:10](=[S:16])[N:9]([CH3:17])[C:8](=[O:18])[CH:7]=1.Cl>O.C(O)C>[NH2:5][C:6]1[N:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[C:10](=[S:16])[N:9]([CH3:17])[C:8](=[O:18])[C:7]=1[N:1]=[O:3]참가 물질
6
실험 절차
Sodium nitrite (0.34 g, 4.9 mmol) in water (1.5 mL) was added to a solution of the amine (1.00 g, 4.7 mmol) in ethanol (7.0 mL) at room temperature. 5M Hydrochloric acid (1.0 mL, 4.9 mmol) was added and the resulting dark red reaction mixture was stirred at room temperature for 2 h. Ethanol (20 mL) was added and the red crystals were filtered off and washed with diethyl ether. Drying of the crystals gave the title compound (0.68 g, 60%).
후처리
- customthe resulting dark red reaction mixture
- filtrationthe red crystals were filtered off
- washwashed with diethyl ether
- customDrying of the crystals
출처 및 근거
- ORD 기록
- ord-4a1b35fa83574166b1335dbbed4eaf79
- 출처 데이터셋
- uspto-grants-2012_08
- 특허 번호
- US08236951B2
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