Benzonitrile, 4-bromo- → 1-Boc-4-[(4-cyanophenyl)amino]-piperidine

HRID 883765

반응식

HRID 883765 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.Br[C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][CH:17]=1.C(C1C=C(NC2CCN(C(OC(C)(C)C)=O)CC2)C=CC=1)#N>>[C:20]([C:19]1[CH:22]=[CH:23][C:16]([NH:1][CH:2]2[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6][CH2:7]2)=[CH:17][CH:18]=1)#[N:21]

참가 물질

4

반응물 3

HCID 12162Benzonitrile, 4-bromo-HCID 12682914-Amino-1-Boc-piperidineHCID 252237961,1-Dimethylethyl 4-[(3-cyanophenyl)amino]-1-piperidinecarboxylate

생성물 1

HCID 185392071-Boc-4-[(4-cyanophenyl)amino]-piperidine

실험 절차

The title compound was prepared from 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate and 4-bromobenzonitrile using a method similar to that described for D5 in Description 5.

출처 및 근거

ORD 기록
ord-bee17b41bf9a4de2be645ca05b96cb90
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08236953B2

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