Ethanol → Ethyl 5-oxo-L-prolinate

HRID 884374노트

반응식

HRID 884374 반응식
[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([OH:9])=[O:8].O=S(Cl)Cl.[CH2:14](O)[CH3:15]>>[CH2:14]([O:8][C:7]([C@@H:2]1[CH2:3][CH2:4][C:5](=[O:6])[NH:1]1)=[O:9])[CH3:15]

참가 물질

4

반응물 3

HCID 702EthanolHCID 7405L-Pyroglutamic AcidHCID 24386Thionyl Chloride

생성물 1

HCID 2724446Ethyl 5-oxo-L-prolinate수율 99%

실험 절차

A suspension of 30.0 g of L-pyroglutamic acid 133 (232 mmol) in 100 ml of anhydrous ethanol was slowly added with 20 ml of SOCl2 (274 mmol, 1.2 eq.) at 0° C. and subsequently stirred for 15 h, and the batch was thawed to room temperature to form a clear solution. For work-up, all volatile components were completely removed under vacuum, the remaining residue was subsequently taken up in 500 ml of ethyl acetate and successively stirred over K2CO3 and MgSO4, each time removing the drying agent by suction. Filtration over a small amount of silica gel and solvent removal under vacuum afforded 36.0 g (230 mmol, 99%) of ester 203 in the form of a slightly yellowish, viscous oil.

후처리

  1. customwas thawed to room temperature
  2. customto form a clear solution
  3. customFor work-up, all volatile components were completely removed under vacuum
  4. stirringsuccessively stirred over K2CO3 and MgSO4
  5. customeach time removing the drying agent by suction
  6. filtrationFiltration
  7. customover a small amount of silica gel and solvent removal under vacuum

출처 및 근거

ORD 기록
ord-940f666d0a6241089324fb38c08035f4
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242105B2

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